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Amanda Hamilton


PhD student: Amanda Hamilton

Amanda Hamilton

Academic background

Physiotherapy BSc (Hons), University of Ulster, 2009


Title of project

Adherence to treatment in non-Cystic Fibrosis (CF) bronchiectasis patients chronically infected with Pseudomonas aeruginosa.


Project outline

Patients with non-Cystic Fibrosis (CF) bronchiectasis who are chronically infected with Pseudomonas aeruginosa usually receive inhaled antibiotics as their use in this patient group has been shown to improve lung function and reduce the rate of respiratory decline. However, despite the use of inhaled antibiotics, some patients chronically infected with P. aeruginosa continue to experience infective pulmonary exacerbations that require the use of additional oral or intravenous antibiotic therapy, with attendant increased morbidity for the patient. It is possible that within this patient group, a relationship exists between poor adherence to inhaled antibiotics and frequency of exacerbation.  Therefore, as no data are currently available on rates of adherence to inhaled antibiotics in adult bronchiectasis patients, the purpose of this study will be to explore adherence to these antibiotics amongst bronchiectasis patients chronically infected with P. aeruginosa and to determine the relationship between adherence and frequency of exacerbation and quality of life. Successful completion of the study may lead to further studies to improve both compliance and the long term outcomes for these patients.



Dr Michael Tunney, Professor Carmel Hughes, School of Pharmacy.

Professor Stuart Elborn, School of Medicine, Dentistry and Biomedical Sciences.

Dr Judy Bradley, Health and Rehabilitation Sciences Research Institute, University of Ulster.


Period of studentship

October 2009 to September 2012